Oncology Podcast

Podcast: How Can We Optimise Treatment Sequencing for mCRC Patients, 3rd Line and Beyond?

Experts discuss how physicians can use the latest data to support optimal treatment sequencing

Prof. Jenny Seligmann

Prof. Shubham Pant

Publication Date

Apr 2023

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Listen to a deep-dive into optimising treatment sequencing for patients with metastatic colorectal cancer, 3rd line and beyond, from Dr Jenny Seligmann and Dr Shubham Pant.

In the podcast, the experts discuss what clinicians should consider when making treatment decisions. You'll learn about

the potential treatment options for patients with advanced mCRC
the latest available data
which patient considerations are important when making treatment decisions

Clinical Takeaways

Molecular profiling has an important role in determining treatment options and sequence
Physicians should consider patient characteristics, such as comorbidities, toxicities from prior treatments, and overall performance status
Treatment from earlier lines of therapy is critical to treatment decisions in the 3^rdline and beyond
There are a lot of new developments in the third-line treatment space for mCRC patients
Patients should receive as many treatment options as possible, and this should be considered during sequencing decisions

Dr Jenny Seligmann gained her MBChB and BMedSci at the University of Aberdeen in 2005 then gained her PhD in 2015 from the University of Leeds on Biomarkers of Prognosis and Prediction of Response in Colorectal Cancer. She was appointed a Cancer Research UK Clinical Trials Fellow in 2015, then a University Academic Fellow and Consultant in Medical Oncology in Leeds in 2017. Her research interests are in clinical trials and biomarkers of prediction of response in colorectal cancer. She is involved in several ongoing clinical trials, including the FOCUS-4 trial and has an ongoing lab-based programme of research. She has been involved in several national and international committees, including the UK Colorectal Clinical Studies Group and is currently the EORTC GI Group Young Investigator. She has received several awards including an ASCO Merit Award in 2013.

Prof. Jenny Seligmann has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Merck Serono, Pierre Fabre and Roche Diagnostics.

Prof. Shubham Pant is a Hematologist-Oncologist and an Associate Professor of Medicine at University of Texas MD Anderson Cancer Center in Houston. He previously served as the Director of Clinical Trials for the Section of Hematology-Oncology and Associate Director of the Tobacco Settlement Endowment Trust (TSET) Phase 1 program, for the Stephenson Cancer Center in Oklahoma City. Furthermore Prof. Pant was the Oncology Lead of the Clinical Research Disease Site Group for Gastrointestinal Cancers and Clinical Research Disease Site Group Chair for Hepatocellular Cancers at the same institute. Prof. Pant completed his fellowship from the Ohio State University, where he was elected Chief Fellow. He previously served as an elected member at large to the Board of Directors for Cancer and Leukemia Group B (CALGB), was the Site Principal Investigator for CALGB and was a Member of the Board of Trustees for ACTION. Prof. Pant served on the Board of Oklahoma Society of Clinical Oncology. He is a participant in the ASCO Leadership Development Program, Class of 2015-16. His awards include the Golden Pillar Award for Outstanding Patient Service in 2012 and 2014, America’s Top Doctors by Castle Connolly and Oklahoma 40 Under 40 in the Oklahoma Magazine. In 2015, he anchored a health show on CNN-IBN India titled: ‘Let’s Talk Health’.

Prof. Shubham Pant has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Zymeworks, Ipsen, Novartis, Janssen, Mirati Therapeutics, Pfizer, Lilly, Xencor, BMS, Astellas Pharma, Purple Biotech, 4D Pharma, Boehringer Ingelheim, NGM Biopharmaceuticals, Arcus Biosciences, Elicio Therapeutics, BioNTech