Oncology

Podcast: Advanced HCC Highlights from ILCA and ESMO 2022

Assoc. Prof. Matthias Pinter

Prof. Dr Jeroen Dekervel

Publication Date

Oct 2022

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In this podcast HCC Experts Prof. Matthias Pinter and Prof. Jeroen Dekervel, discuss and debate the clinical implications of new HCC Phase 3 clinical trials data presented at the ILCA and ESMO congresses, 2022. They discuss Immuno-oncology agents and their place in the upcoming updated guidance such as the proposed new ILCA Systemic Therapies Guidance algorithm. They also discuss new treatment options in first line for advanced HCC presented at ESMO including the three late breaking abstracts LEAP-002, RATIONALE-301 and tislelizumab monotherapy trials. The latter two studying first-line treatment with an anti-PD1 antibody with or without a kinase inhibitor in patients with advanced hepatocellular carcinoma. The experts evaluate and provide their insights into how to integrate these new treatments for HCC in the clinical practice.

Dr Matthias Pinter works at the Medical University of Vienna in Austria where he also received both his MD and PhD. He is board-certified for Internal Medicine and Gastroenterology and Hepatology. Since 2017, he has led the hepatocellular carcinoma programme and research group at the Division of Gastroenterology and Hepatology at the Medical University of Vienna. His main research interests include the systemic treatment of liver cancer, particularly the identification of prognostic markers and scores that may help to identify patients most likely to benefit from specific therapies. To broaden his knowledge and expertise in basic research and experimental oncology, he worked as a research fellow and postdoc at renowned institutions, including the University of Bern in Switzerland and the Massachusetts General Hospital/Harvard Medical School in the United States. He has published numerous original papers and review articles on liver cancer in prestigious peer-reviewed journals covering the categories oncology, gastroenterology and hepatology, and radiology.

Assoc. Prof. Matthias Pinter has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Bayer, BMS, Ipsen, Eisai, Lilly, MSD and Roche.

Prof. Dr Jeroen Dekervel is a GI oncologist working at the Digestive Oncology Unit of UZ Leuven, Belgium. In daily clinical practice, he treats all kinds of gastrointestinal malignancies at one of the largest clinics of its kind in Europe. He is an associate professor at the KU Leuven, where his research focuses on unraveling the reasons for success and failure of immunotherapies in hepatocellular carcinoma, using a variety of single cell techniques. He is a member of ESMO and ASCO, as well as part of the ESMO upper GI faculty as a mentee.

Prof. Dr Jeroen Dekervel has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Bayer, Amgen, BMS, Eisai, Ipsen, Lilly, Merck, MSD, Roche, Novartis and Servier.