Hemostasis and bleeding disorders Video

How Coagulation Cascade Deficiencies Lead to Bleeding Disorders

A short video from bleeding disorder experts

Dr Vickie McDonald

Prof. Ana Boban

Publication Date

Jul 2023

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Many HCPs come into contact with patients with bleeding disorders like von Willebrand disease (VWD) or haemophilia. In this short animated video, guided by haematologists Dr Vickie McDonald and Prof. Ana Boban, you'll learn about:

Differences between primary and secondary haemostasis
The importance of interpreting laboratory coagulation
Consequences of the deficiencies in the coagulation cascade for von Willebrand disease and haemophilia A

Clinical Takeaways

Inherent bleeding disorders may be difficult to recognize and diagnose; better understanding of the primary and secondary haemostasis can ensure proper diagnosis and optimized care of those affected
Clotting time tests are useful tools to recognize and diagnose people with a potential bleeding disorder; consult a haematologist when in doubt
Patients with VWD may have normal PT and aPTT values, where more severe VWD can result in a prolonged aPTT due to low factor VIII levels; patients with haemophilia A have a prolonged aPPT value due low activity of factor VIII

Dr Vickie McDonald is a consultant haematologist at the Royal London Hospital, London, UK. Her main interests are disorders of coagulation, including ITP. She looks after patients with inherited and acquired disorders of clotting and platelets and runs specialist clinics in ITP. She is an honorary senior lecturer at Queen Mary University of London and is the national chief investigator for the UK ITP registry in addition to the PI and CI for several trials in ITP, both early and late phase studies.

Dr Vickie McDonald has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Abbvie, Amgen, Grifols, Novartis and Sobi.

Dr Ana Boban is Head of Haemophilia Centre at the University Hospital Centre Zagreb and Associate Professor of Internal Medicine at the School of Medicine of the University of Zagreb, Croatia. She has specialist degrees in Internal Medicine and Haematology. Dr Boban’s clinical work is in the field of benign haematology with the focus on bleeding disorders and thrombosis. Dr Boban is a member of national and international scientific and medical societies in the field of haemostasis and thrombosis and is currently serving as Executive Committee member of EAHAD. Dr Boban’s research interests include clinical haemophilia, carriers of haemophilia, von Willebrand disease, anticoagulant treatments and ITP.

Prof. Ana Boban has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Bayer, CSL Behring, Novo Nordisk, Octopharma, Pfizer, Roche, Sobi, Swixx Biopharma and Takeda.