{"id":120325,"date":"2023-07-12T18:19:17","date_gmt":"2023-07-12T16:19:17","guid":{"rendered":"https:\/\/test.lab.cor2ed.com\/cms\/?post_type=programmes&#038;p=120325"},"modified":"2024-10-25T13:34:59","modified_gmt":"2024-10-25T11:34:59","slug":"update-asco-wcgic-2023","status":"publish","type":"programmes","link":"https:\/\/test.lab.cor2ed.com\/cms\/precision-oncology-connect\/programmes\/update-asco-wcgic-2023\/","title":{"rendered":"Conference Update: ASCO and WCGIC 2023"},"content":{"rendered":"<p>In this clinical update video, Prof. Andrea Sartore-Bianchi shares his perspective on key data from ASCO and the World Conference on Gastrointestinal Cancer (WCGIC), 2023.<\/p>\n<p>He reviews data from:<\/p>\n<ul>\n<li>DESTINY-PanTumor02 trial in <strong>HER2-expressing solid tumours<\/strong>\u00a0<\/li>\n<li>KontRASt-01 trial in<strong> non-small cell lung cancer<\/strong> (NSCLC)<\/li>\n<li>ADVL 1823 trial in<strong> infantile fibrosarcoma<\/strong><\/li>\n<li>A retrospective study on molecular profiling on <strong>advanced biliary tract cancers<\/strong><\/li>\n<\/ul>\n<p><\/p>\n<h3><strong>Clinical Takeaways<\/strong><\/h3>\n<ul>\n<li>\n<p><strong>DESTINY-PanTumour02:<\/strong> Study shows T-DXd to be a potential new treatment option for patients with HER2-expressing solid tumours, with higher efficacy in IHC 3+ and efficacy also in anti-HER2 pre-treated patients<\/p>\n<\/li>\n<li>\n<p><strong>KontRASt-01:<\/strong> JDQ443 exhibits potent antitumour activity in NSCLC with good disease control and partial responses, as well as a good tolerability profile<\/p>\n<\/li>\n<li>\n<p><strong>ADVL1823:<\/strong> First data in first-line treatment with larotrectinib in the NTRK+ infantile fibrosarcoma population, with data suggesting that local control (surgery) remains important to achieve long-term results<\/p>\n<\/li>\n<li>\n<p><strong>Molecular Profiling in Biliary Cancers (BTC):<\/strong> the study highlights the importance of conducting NGS upfront for BTC. Treatment with a matched targeted therapeutic provides benefit in terms of DCR, PFS and OS<\/p>\n<\/li>\n<\/ul>\n<h2>\u00a0<\/h2>\n<h2>Selected abstracts<\/h2>\n<h3>ASCO 2023<\/h3>\n<p><strong>Efficacy and safety of trastuzumab deruxtecan (T-DXd) in patients (pts) with HER2-expressing solid tumors: DESTINY-PanTumor02 (DP-02) interim results.<\/strong><\/p>\n<ul>\n<li>Abstract: LBA3000<\/li>\n<li><span class=\"fabric-text-color-mark\" data-renderer-mark=\"true\" data-text-custom-color=\"#2b3341\">Presenter:<\/span> <span class=\"fabric-text-color-mark\" data-renderer-mark=\"true\" data-text-custom-color=\"#4d4d4d\">Funda Meric-Bernstam, MD<\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p class=\"chaptertitle\"><strong>KontRASt-01 update: Safety and efficacy of JDQ443 in\u00a0<i>KRAS G12C<\/i>-mutated solid tumors including non-small cell lung cancer (NSCLC).<\/strong><\/p>\n<ul>\n<li>Abstract: 9007<\/li>\n<li><span class=\"fabric-text-color-mark\" data-renderer-mark=\"true\" data-text-custom-color=\"#2b3341\">Presenter: <\/span><span class=\"fabric-text-color-mark\" data-renderer-mark=\"true\" data-text-custom-color=\"#172b4d\">Philippe Alexandre Cassier MD, PhD<\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><strong>Phase 2 study of larotrectinib in children with newly diagnosed infantile fibrosarcoma (IFS): Children\u2019s Oncology Group (COG) ADVL1823 cohort A.<\/strong><\/p>\n<ul>\n<li>Abstract: 10008<\/li>\n<li><span class=\"fabric-text-color-mark\" data-renderer-mark=\"true\" data-text-custom-color=\"#2b3341\">Presenter: <\/span><span class=\"fabric-text-color-mark\" data-renderer-mark=\"true\" data-text-custom-color=\"#4d4d4d\">Theodore Willis Laetsch, MD<\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>WCGIC 2023<\/h3>\n<p><strong data-renderer-mark=\"true\"><span class=\"fabric-text-color-mark\" data-renderer-mark=\"true\" data-text-custom-color=\"#172b4d\">SO-4 Impact of molecular profiling on survival in patients with advanced biliary tract cancers.<\/span><\/strong><\/p>\n<ul>\n<li><span class=\"fabric-text-color-mark\" data-renderer-mark=\"true\" data-text-custom-color=\"#172b4d\">Short Oral Presentation Clinical Biliary Tract Cancer, <\/span><span class=\"fabric-text-color-mark\" data-renderer-mark=\"true\" data-text-custom-color=\"#172b4d\">Biomarkers and Translational Research<\/span><\/li>\n<li>Presenter: Leony Anton<\/li>\n<\/ul>\n","protected":false},"author":{"id":1330,"first_name":"Melissa","last_name":"Turner","nickname":"melissa.turner@cor2ed.com","email":"melissa.turner@cor2ed.com"},"featured_media":124024,"menu_order":3,"template":"","labels":[61,62,63,8,57,75,13,67],"keywords":[],"class_list":["post-120325","programmes","type-programmes","status-publish","has-post-thumbnail","hentry","labels-liver","labels-liver-cancer","labels-liver-oncology","labels-lung-cancer-medical-educational-programmes","labels-oncology","labels-paediatrics","labels-onco-genetics-medical-educational-programmes","labels-rare-disease"],"programme_info_project-code":"  BA-23-06-08-L","programme_info_type":"video","programme_info_sub-type":"","programme_info_medical-affairs":"yes","programme_info_series":"","programme_info_series-uid":"","programme_info_series-number":"","programme_info_multiple-media":"","programme_info_subtitle":"<p>An expert perspective on the latest data in precision 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