{"id":1769,"date":"2021-10-28T19:32:24","date_gmt":"2021-10-28T19:32:24","guid":{"rendered":"https:\/\/test.lab.cor2ed.com\/cms\/programmes\/podcast-series-best-treatment-regimen-multiple-myeloma-relapsed-refractory\/"},"modified":"2023-11-17T10:39:22","modified_gmt":"2023-11-17T09:39:22","slug":"podcast-series-best-treatment-regimen-multiple-myeloma-relapsed-refractory","status":"publish","type":"programmes","link":"https:\/\/test.lab.cor2ed.com\/cms\/lymphoma-myeloma-connect\/programmes\/podcast-series-best-treatment-regimen-multiple-myeloma-relapsed-refractory\/","title":{"rendered":"Podcast: Choosing the Best Treatment Regimen in RRMM (Episode 2 of 3)"},"content":{"rendered":"<p>Listen to Episode 2: Choosing the Best Treatment Regimen in RRMM<\/p>\n<p><\/p>\n<div class=\"et_pb_module et_pb_text et_pb_text_9  et_pb_text_align_left et_pb_bg_layout_light\">\n<div class=\"et_pb_text_inner\">\n<p><strong>Episode 2 \u2013 The Relapsed\/Refractory Setting<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p>In the\u00a0second episode, Dr. Richter and Dr. Ramasamy explore how to select the best treatment approach in the second-line setting and beyond. They discuss at what point they consider a patient to actually be in relapse.\u00a0The decision on which treatment option to select in the second-line and beyond mostly depends on refractoriness to other drugs. With an increasing number of novel treatment options, choosing a regimen that does not include a drug the patient is refractory to is becoming easier. However, many challenges remain when making these treatment decisions. The experts share their experiences with CAR-T and other T cell redirection therapies, and when to use it in the treatment sequence, concluding with a look into the future of myeloma treatment.<\/p>\n<p>&nbsp;<\/p>\n<p>In the\u00a0<span style=\"text-decoration: underline\"><strong><a href=\"https:\/\/test.lab.cor2ed.com\/cms\/programmes\/podcast-series-best-treatment-regimen-multiple-myeloma-newly-diagnosed\" target=\"_blank\" rel=\"noopener\">first podcast episode<\/a><\/strong><\/span>, Dr. Joshua Richter and Dr. Karthik Ramasamy discuss how to select the best approach in newly diagnosed patients with MM. They discuss personalising therapy, both in the transplant setting as well as in patients who are not eligible for transplantation. They also consider the impact of MRD negativity in clinical practice. The experts agree that the goal of treatment is to induce deep remissions and debate whether triple or quadruplet therapy is required to achieve this goal. The final topic that the experts discuss is continuous vs fixed-duration maintenance therapy.<\/p>\n<p>&nbsp;<\/p>\n<p>In the <span style=\"text-decoration: underline\"><strong><a href=\"https:\/\/test.lab.cor2ed.com\/cms\/programmes\/podcast-series-best-treatment-regimen-multiple-myeloma-high-risk-cytogenetics\">third podcast episode<\/a><\/strong><\/span>, Dr. Mar\u00eda Victoria Mateos and Dr. Alexander Lesokhin discuss how they choose the best treatment regimen for patients with multiple myeloma and a high-risk cytogenetic profile. They discuss the treatment options available for patients with high-risk cytogenetics in the US and in Europe and the factors they consider in these decisions in their clinical practice. Although the prior treatment is the most important consideration in the relapsed setting, the type of cytogenetic abnormality also plays a role. The experts specifically discuss treatment decisions in patients with extramedullary multiple myeloma: a difficult-to-treat population. The future of myeloma treatment is also explored, looking at trial design to better meet the needs of patients with a high-risk cytogenetic profile and the role of CAR-T and bispecific antibodies in this population.<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center\">This LYMPHOMA &amp; MYELOMA CONNECT podcast series is also available on <span style=\"text-decoration: underline\"><strong><a href=\"https:\/\/cor2ed-medical-education.castos.com\/episodes\/choosing-the-best-treatment-regimen-in-multiple-myeloma-episode-2-the-relapsedrefractory-setting\" target=\"_blank\" rel=\"noopener\">Castos<\/a><\/strong><\/span>, <span style=\"text-decoration: underline\"><strong><a href=\"https:\/\/open.spotify.com\/episode\/2V4t1e2zYzjCqtIfWyaZbc?si=44dfd40b087748e9\" target=\"_blank\" rel=\"noopener\">Spotify<\/a><\/strong><\/span>, <span style=\"text-decoration: underline\"><strong><a href=\"https:\/\/podcasts.apple.com\/us\/podcast\/choosing-the-best-treatment-regimen-in-multiple\/id1567226398?i=1000539284025\" target=\"_blank\" rel=\"noopener\">Apple Podcasts<\/a><\/strong><\/span>, and <span style=\"text-decoration: underline\"><strong><a href=\"https:\/\/podcasts.google.com\/feed\/aHR0cHM6Ly9jb3IyZWQtbWVkaWNhbC1lZHVjYXRpb24uY2FzdG9zLmNvbS9mZWVk\/episode\/aHR0cHM6Ly9jb3IyZWQtbWVkaWNhbC1lZHVjYXRpb24uY2FzdG9zLmNvbS9wb2RjYXN0cy8yNTY5Ni9lcGlzb2Rlcy9jaG9vc2luZy10aGUtYmVzdC10cmVhdG1lbnQtcmVnaW1lbi1pbi1tdWx0aXBsZS1teWVsb21hLWVwaXNvZGUtMS10aGUtbmV3bHktZGlhZ25vc2VkLXNldHRpbmc?sa=X&amp;ved=0CA0QkfYCahcKEwio-qOPw9vzAhUAAAAAHQAAAAAQAQ\" target=\"_blank\" rel=\"noopener\">Google Podcasts<\/a><\/strong><\/span>.<\/p>\n<\/div>\n<\/div>\n","protected":false},"author":{"id":1,"first_name":"Francisco","nickname":"Superadmin","email":"jose.santos@cor2ed.com"},"featured_media":1767,"menu_order":0,"template":"","labels":[3],"keywords":[],"class_list":["post-1769","programmes","type-programmes","status-publish","has-post-thumbnail","hentry","labels-myeloma-medical-educational-programmes"],"programme_info_project-code":"","programme_info_type":"podcast","programme_info_sub-type":"","programme_info_medical-affairs":"","programme_info_series":"yes","programme_info_series-uid":"1578","programme_info_series-number":"2","programme_info_multiple-media":"","programme_info_subtitle":"<p>In this second episode, Dr. Joshua Richter and Dr. Karthik Ramasamy discuss their views on choosing the best treatment regimen in relapsed\/refractory multiple myeloma (RRMM)<\/p>","programme_info_supporter-disclaimer":"","programme_info_acknowledgement":"","programme_info_learning-objetives":"","programme_info_pop-up":"","programme_info_pop-up-text":"","programme_info_pop-up-button-1":"","programme_info_pop-up-button-2":"","programme_therapeutic-areas_therapeutic-areas":["641"],"programme_connect_connect":"789","programme_experts_experts":["119","477"],"programme_partnerships_partnerships":"","programme_accreditations_accreditations":["191663"],"programme_programmes_programmes":"","programme_connects_connects":"","programme_users_users":"","programme_medias_media_collection":"1","programme_medias_media_show_0":"","programme_medias_media_group_0":"","programme_medias_media_project-code_0":"","programme_medias_media_title_0":"","programme_medias_media_subtitle_0":"","programme_medias_media_description_0":"","programme_medias_media_type_0":"castos","programme_medias_media_youtube_0":"","programme_medias_media_vimeo_0":"","programme_medias_media_castos_0":"729534","programme_medias_media_castos-video_0":"","programme_medias_media_spotify_0":"2V4t1e2zYzjCqtIfWyaZbc","programme_medias_media_spotify-video_0":"","programme_medias_media_apple_0":"1000539284025","programme_medias_media_apple-video_0":"","programme_medias_media_google_0":"aHR0cHM6Ly9jb3IyZWQtbWVkaWNhbC1lZHVjYXRpb24uY2FzdG9zLmNvbS9wb2RjYXN0cy8yNTY5Ni9lcGlzb2Rlcy9jaG9vc2luZy10aGUtYmVzdC10cmVhdG1lbnQtcmVnaW1lbi1pbi1tdWx0aXBsZS1teWVsb21hLWVwaXNvZGUtMi10aGUtcmVsYXBzZWRyZWZyYWN0b3J5LXNldHRpbmc?sa=X&ved=0CAUQkfYCahcKEwjA2aerwvqBAxUAAAAAHQAAAAAQAQ","programme_medias_media_google-video_0":"","programme_medias_media_url_0":"","programme_medias_media_scorm_0":"","programme_medias_media_file_0":"","programme_medias_media_duration_0":"25","programme_medias_media_overview_0":"","programme_medias_media_audio-transcript_0":"","programme_medias_media_additional-description_0":"","programme_medias_media_supporter-disclaimer_0":"","programme_medias_media_acknowledgement_0":"","programme_medias_media_learning-objetives_0":"","programme_medias_media_custom-description-title_0":"","programme_medias_media_custom-description-text_0":"","programme_medias_media_connect_0":"","programme_medias_media_experts_0":"","programme_medias_media_partnerships_0":"","programme_medias_media_connects_0":"","programme_medias_media_0_documents_collection":"1","programme_medias_media_0_documents_file_0":"1768","programme_medias_media_0_documents_button_0":"DOWNLOAD 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