{"id":188348,"date":"2023-07-07T10:12:04","date_gmt":"2023-07-07T08:12:04","guid":{"rendered":"https:\/\/test.lab.cor2ed.com\/cms\/n-connect\/programmes\/new-oral-endocrine-therapy-options-for-patients-with-advanced-or-metastatic-er-breast-cancer-episode-4\/"},"modified":"2023-11-17T10:38:51","modified_gmt":"2023-11-17T09:38:51","slug":"endocrine-therapy-advanced-breast-cancer-4","status":"publish","type":"programmes","link":"https:\/\/test.lab.cor2ed.com\/cms\/breast-cancer-connect\/programmes\/endocrine-therapy-advanced-breast-cancer-4\/","title":{"rendered":"New Oral Endocrine Therapy Options for Patients with Advanced or Metastatic ER+ Breast Cancer &#8211; Episode 4"},"content":{"rendered":"<p style=\"text-align: left\">Medical experts come together to share their views in this on-demand webinar replay of an interactive online discussion:<\/p>\n<p>&nbsp;<\/p>\n<h3 style=\"text-align: center\"><strong>New Oral Endocrine Therapy Options for Patients with Advanced or Metastatic ER+ Breast Cancer<\/strong><\/h3>\n<p>&nbsp;<\/p>\n<ul>\n<li>\n<p>The independent expert panel discussed oral SERDs efficacy and safety profiles in patients with ER+\/HER2- advanced or metastatic breast cancer and their place in the treatment landscape<\/p>\n<\/li>\n<li>\n<p>They also covered how to optimise treatment selection and sequencing in ER+\/HER2- advanced or metastatic breast cancer and why, when and how to test for ESR1 mutation<\/p>\n<\/li>\n<li>\n<p>The event concluded with speakers and participants engaging in a Q&amp;A to address pressing questions<\/p>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>Watch the replay, broken down into 4 digestible videos, download the accompanying slides, and take the accredited e-learning using the blue button below the videos.<\/p>\n<p><\/p>\n<h3><strong>Clinical Takeaways<\/strong><\/h3>\n<ul style=\"font-weight: 400\">\n<li>\n<p>Elacestrant is the 1<sup>st<\/sup>\u00a0oral SERD to be FDA approved (January 2023)\u00a0for postmenopausal women or adult men with ER+\/HER2-,\u00a0<em>ESR1<\/em>-mutated advanced or metastatic breast cancer<\/p>\n<\/li>\n<\/ul>\n<ul style=\"font-weight: 400\">\n<li style=\"list-style-type: none\">\n<ul>\n<li>\n<p>FDA approved Guardant360 CDx assay as a companion diagnostic device to identify patients with ER+\/HER2- advanced or metastatic breast cancer for treatment with elacestrant<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<li>\n<p>With the aim of redefining treatment landscapes for ER+\/HER2- advanced and metastatic breast cancer, several oral SERDs are in clinical development both as monotherapy and in combination therapy with other targeted therapies, including CDK4\/6i\u00a0<\/p>\n<\/li>\n<li>\n<p><em>ESR1<\/em>, PI3K, CDK4\/6, BRCA, and AKT pathways alterations can be used as targets to guide treatment selection and sequencing decisions in ER+\/HER2- advanced or metastatic breast cancer<\/p>\n<\/li>\n<li>\n<p><em>ESR1\u00a0<\/em>mutational status can be determined without repeated tissue biopsy of a metastatic site; instead, it can be done reliably by liquid biopsy at recurrence or progression on ET<\/p>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>This programme is endorsed by:<\/p>\n<p><a href=\"https:\/\/www.gruposolti.org\/\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-87078\" src=\"https:\/\/test.lab.cor2ed.com\/cms\/wp-content\/uploads\/2023\/05\/BR2301-SOLTI-PAG-logo.png\" alt=\"SOLTI PAG logo\" width=\"300\" height=\"142\" \/><\/a><a href=\"https:\/\/graspcancer.org\/\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone  wp-image-87001\" src=\"https:\/\/test.lab.cor2ed.com\/cms\/wp-content\/uploads\/2023\/06\/grasp-logo-web-rgb-from-Isabel-Andrews-300x300.png\" alt=\"GRASP logo\" width=\"213\" height=\"213\" srcset=\"https:\/\/test.lab.cor2ed.com\/cms\/wp-content\/uploads\/2023\/06\/grasp-logo-web-rgb-from-Isabel-Andrews-300x300.png 300w, https:\/\/test.lab.cor2ed.com\/cms\/wp-content\/uploads\/2023\/06\/grasp-logo-web-rgb-from-Isabel-Andrews-150x150.png 150w, https:\/\/test.lab.cor2ed.com\/cms\/wp-content\/uploads\/2023\/06\/grasp-logo-web-rgb-from-Isabel-Andrews-768x768.png 768w, https:\/\/test.lab.cor2ed.com\/cms\/wp-content\/uploads\/2023\/06\/grasp-logo-web-rgb-from-Isabel-Andrews.png 1000w\" sizes=\"auto, (max-width: 213px) 100vw, 213px\" \/><\/a><\/p>\n","protected":false},"author":{"id":1330,"first_name":"Melissa","last_name":"Turner","nickname":"melissa.turner@cor2ed.com","email":"melissa.turner@cor2ed.com"},"featured_media":188350,"menu_order":0,"template":"","labels":[],"keywords":[],"class_list":["post-188348","programmes","type-programmes","status-publish","has-post-thumbnail","hentry"],"programme_info_project-code":"ME 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