Listen to the second episode – PSMA-targeted radiopharmaceuticals<\/p>\n
<\/p>\n
In this GU CONNECT podcast series international experts, Assoc. Prof. Tanya Dorff <\/strong>and Dr. Phillip Koo<\/strong>, from the field of GU Oncology and Nuclear Medicine, discuss the latest developments in the field of radiopharmaceuticals<\/strong> and their use in prostate cancer<\/strong>. \u00a0Episode 2<\/strong> focuses on PSMA-targeted radiopharmaceuticals.<\/p>\n Episode two focuses on\u00a0PSMA-targeted radiopharmaceuticals<\/strong>\u00a0and how PSMA can be a therapeutic target as well as for imaging. Efficacy and safety data from the phase 2 TheraP study are discussed which investigated lutetium-PSMA versus cabazitaxel in patients with mCRPC who had progressed on docetaxel.<\/p>\n The experts also discuss the ongoing\u00a0VISION<\/strong>\u00a0trial and what the results may mean for clinical practice as well as other ongoing trials looking at lutetium-PSMA in combination with other prostate cancer therapies such as PARP inhibitors, immunotherapies, hormonal therapies and chemotherapy. Treatment sequencing is also considered in terms of where lutetium-PSMA fits into clinical practice for mCRPC patients and how the treatment compares to Radium-223.<\/p>\n In the first episode, the experts focus on the alpha emitter,\u00a0radium-223<\/strong>\u00a0which received regulatory approval on the basis of the phase 3\u00a0ALSYMPCA<\/strong>\u00a0trial in patients with metastatic castration-resistant prostate cancer (mCRPC) and symptomatic bone metastases. They consider mechanism of action and discuss key results from the trial and the safety profile.<\/p>\n The experts also review the\u00a0ERA-223<\/strong>\u00a0and\u00a0PEACE-III<\/strong> randomised trials which investigated the use of radium-223 in combination with next-generation androgen receptor inhibitors (ARI\u2019s).\u00a0 A number of real-world evidence studies are also reviewed as the experts consider where radium-223 fits into the overall treatment sequence for mCRPC patients. Radiation safety and general considerations for delivering therapy with radiopharmaceuticals are also discussed.<\/p>\n","protected":false},"author":{"id":1,"first_name":"Francisco","nickname":"Superadmin","email":"jose.santos@cor2ed.com"},"featured_media":2093,"menu_order":0,"template":"","labels":[4],"keywords":[],"class_list":["post-2094","programmes","type-programmes","status-publish","has-post-thumbnail","hentry","labels-genitourinary-oncology-medical-educational-programmes"],"programme_info_project-code":"","programme_info_type":"podcast","programme_info_sub-type":"","programme_info_medical-affairs":"","programme_info_series":"","programme_info_series-uid":"","programme_info_series-number":"","programme_info_multiple-media":"","programme_info_subtitle":" Episode 2 focuses on PSMA-targeted 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