{"id":35358,"date":"2023-02-02T16:58:34","date_gmt":"2023-02-02T15:58:34","guid":{"rendered":"https:\/\/test.lab.cor2ed.com\/cms\/?post_type=programmes&#038;p=35358"},"modified":"2023-11-17T10:39:00","modified_gmt":"2023-11-17T09:39:00","slug":"severe-primary-igf1-deficiency-spigfd","status":"publish","type":"programmes","link":"https:\/\/test.lab.cor2ed.com\/cms\/pe-connect\/programmes\/severe-primary-igf1-deficiency-spigfd\/","title":{"rendered":"Recognising and Diagnosing Severe Primary IGF-I Deficiency (SPIGFD)"},"content":{"rendered":"<p>It can be challenging to differentiate severe primary IGF-I deficiency from other conditions of short stature. In this micro learning, expert paediatric endocrinologists from PE CONNECT share their knowledge of identifying and treating SPIGFD in practice.<\/p>\n<p>You&#8217;ll learn how to recognise the typical presentation of SPIGFD and how a combination of clinical assessment and biochemical analysis of the GH-IGF-I axis can support your diagnosis of this rare condition.<\/p>\n<p>After watching the video, take the assessment to earn your CME credit.<\/p>\n<p>&nbsp;<\/p>\n<h4><strong>Clinical Takeaways<\/strong><\/h4>\n<ul>\n<li><span class=\"fabric-text-color-mark\" data-renderer-mark=\"true\" data-text-custom-color=\"#5ba3dd\">Severe primary IGF-I deficiency<\/span> <span class=\"fabric-text-color-mark\" data-renderer-mark=\"true\" data-text-custom-color=\"#5d8298\">(SPIGFD) generally presents as<\/span> <span class=\"fabric-text-color-mark\" data-renderer-mark=\"true\" data-text-custom-color=\"#5ba3dd\">classical Laron syndrome,<\/span> <span class=\"fabric-text-color-mark\" data-renderer-mark=\"true\" data-text-custom-color=\"#5d8298\">but<\/span> <span class=\"fabric-text-color-mark\" data-renderer-mark=\"true\" data-text-custom-color=\"#5ba3dd\">non-classical cases with mild or moderate phenotypes <\/span><span class=\"fabric-text-color-mark\" data-renderer-mark=\"true\" data-text-custom-color=\"#5d8298\">should also be considered<\/span><\/li>\n<li><span class=\"fabric-text-color-mark\" data-renderer-mark=\"true\" data-text-custom-color=\"#5ba3dd\">An endocrine investigation<\/span> <span class=\"fabric-text-color-mark\" data-renderer-mark=\"true\" data-text-custom-color=\"#5d8298\">should be conducted<\/span> <span class=\"fabric-text-color-mark\" data-renderer-mark=\"true\" data-text-custom-color=\"#5ba3dd\">to assess the GH-IGF-I axis<\/span> <span class=\"fabric-text-color-mark\" data-renderer-mark=\"true\" data-text-custom-color=\"#5d8298\">to ensure appropriate diagnosis<\/span><\/li>\n<li><span class=\"fabric-text-color-mark\" data-renderer-mark=\"true\" data-text-custom-color=\"#5ba3dd\">Diagnosis of<\/span> <span class=\"fabric-text-color-mark\" data-renderer-mark=\"true\" data-text-custom-color=\"#5ba3dd\">severe primary IGF-I deficiency<\/span> <span class=\"fabric-text-color-mark\" data-renderer-mark=\"true\" data-text-custom-color=\"#5d8298\">requires severe short stature, low serum IGF-I and normal or increased growth hormone secretion, as well as lack of other pathology<\/span><\/li>\n<li><span class=\"fabric-text-color-mark\" data-renderer-mark=\"true\" data-text-custom-color=\"#5ba3dd\">An early and correct diagnosis<\/span> <span class=\"fabric-text-color-mark\" data-renderer-mark=\"true\" data-text-custom-color=\"#5d8298\">is essential to allow children to achieve their full growth potential with appropriate treatment<\/span><\/li>\n<\/ul>\n<p><\/p>\n<p>&nbsp;<\/p>\n<p>This SPIGFD micro learning programme is endorsed by:<\/p>\n<p><a href=\"https:\/\/www.magicfoundation.org\/\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone  wp-image-37686\" src=\"https:\/\/test.lab.cor2ed.com\/cms\/wp-content\/uploads\/2023\/02\/PE2300_The_Magic_Foundation_Logo-removebg-preview-300x207.png\" alt=\"\" width=\"175\" height=\"121\" srcset=\"https:\/\/test.lab.cor2ed.com\/cms\/wp-content\/uploads\/2023\/02\/PE2300_The_Magic_Foundation_Logo-removebg-preview-300x207.png 300w, https:\/\/test.lab.cor2ed.com\/cms\/wp-content\/uploads\/2023\/02\/PE2300_The_Magic_Foundation_Logo-removebg-preview.png 600w\" sizes=\"auto, (max-width: 175px) 100vw, 175px\" \/><\/a><\/p>\n<p>The MAGIC Foundation is a national nonprofit organization created to provide support services for the families of children afflicted with a wide variety of chronic and\/or critical disorders, syndromes and diseases that affect a child&#8217;s growth. Some of the diagnoses are quite common while others are very rare.<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/www.hgfound.org\/\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-37682\" src=\"https:\/\/test.lab.cor2ed.com\/cms\/wp-content\/uploads\/2023\/02\/PE2300_human-growth-foundation_logo-300x82.png\" alt=\"\" width=\"300\" height=\"82\" srcset=\"https:\/\/test.lab.cor2ed.com\/cms\/wp-content\/uploads\/2023\/02\/PE2300_human-growth-foundation_logo-300x82.png 300w, https:\/\/test.lab.cor2ed.com\/cms\/wp-content\/uploads\/2023\/02\/PE2300_human-growth-foundation_logo.png 438w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>The Human Growth Foundation is a world leading nonprofit organization focused on children and adults with rare growth and bone conditions. We provide research, education, patient support, and advocacy to help improve the quality of life for those affected by these disorders. Our vision is that all people with rare growth or bone conditions have access to the best care possible.<\/p>\n","protected":false},"author":{"id":1330,"first_name":"Melissa","last_name":"Turner","nickname":"melissa.turner@cor2ed.com","email":"melissa.turner@cor2ed.com"},"featured_media":36129,"menu_order":0,"template":"","labels":[17],"keywords":[],"class_list":["post-35358","programmes","type-programmes","status-publish","has-post-thumbnail","hentry","labels-pediatric-endocrinology-medical-educational-programmes"],"programme_info_project-code":"IP 22-04-03","programme_info_type":"","programme_info_sub-type":"","programme_info_medical-affairs":"","programme_info_series":"","programme_info_series-uid":"","programme_info_series-number":"","programme_info_multiple-media":"","programme_info_subtitle":"<p>A micro learning programme from paediatric 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